Liver damage associated with perhexiline maleate.
نویسندگان
چکیده
منابع مشابه
Liver damage due to perhexiline maleate.
Two middle-aged men, who had received perhexiline in recommended dosage, showed clinical and histological evidence of severe hepatic damage, and one of them died. Histological study of the livers showed a striking resemblance to alcoholic hepatitis.
متن کاملPerhexiline maleate toxicity on human liver cell lines.
When added to the culture medium of human liver cell lines, perhexiline maleate induced formation of numerous myeloid bodies containing unicentric or multicentric smooth membranes within a few days. The nine lysosomal enzyme activities studied, except for beta-galactosidase which decreased, remained unchanged. These results indicate that on cultured human liver cells perhexiline maleate has an ...
متن کاملPolymorphic hydroxylation of perhexiline maleate in man.
Long term perhexiline maleate therapy causes peripheral neuropathy and hepatic damage in certain subjects. An association between these adverse reactions and a genetically determined relative inability to hydroxylate debrisoquine has been described. This association could indicate either that the effects of perhexiline impair debrisoquine oxidation thus producing a phenocopy, or that perhexilin...
متن کاملPapilloedema and hepatic dysfunction apparently induced by perhexiline maleate (Pexid).
A patient developed papilloedema and hepatic dysfunction while being treated with perhexiline maleate. These later regressed when the drug was withdrawn. Patients should be monitored for these potentially serious side-effects while on this drug.
متن کاملComparative trial of perhexiline maleate and oxprenolol in patients with angina pectoris.
A random single-blind study of oxprenolol against perhexiline has been undertaken in angina pectoris. Both drugs were effective in treatment (P less than 0.01) but perhexiline was better than oxprenolol (P less than 0.05), 12 of the 14 patients preferring perhexiline. Offset against this was the greater incidence of side effects with perhexiline, including one patient who later developed periph...
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ژورنال
عنوان ژورنال: Gut
سال: 1979
ISSN: 0017-5749
DOI: 10.1136/gut.20.3.186